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Mol Cancer. 2015 Feb 15;14:43. doi: 10.1186/s12943-015-0291-7.

The role of the insulin-like growth factor-1 system in breast cancer.

Author information

1
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Goudi, Athens, Greece. panutsoschr@hotmail.com.
2
Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. msaouel@gmail.com.
3
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Goudi, Athens, Greece. mkoutsil@med.uoa.gr.

Abstract

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.

PMID:
25743390
PMCID:
PMC4335664
DOI:
10.1186/s12943-015-0291-7
[Indexed for MEDLINE]
Free PMC Article

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