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Nat Rev Drug Discov. 2015 Apr;14(4):261-78. doi: 10.1038/nrd4505. Epub 2015 Mar 6.

Targeting the translation machinery in cancer.

Author information

1
1] Goodman Cancer Research Centre, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [2] McGill University Health Centre, Division of Gastroenterology, 687 Pine Avenue West, Montreal, Quebec, H3A1A1, Canada. [3].
2
1] Goodman Cancer Research Centre, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [2] Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada. [3].
3
1] Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, Canada. [2] Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, H2W 1S6, Canada. [3].
4
1] Goodman Cancer Research Centre, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [2] Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada.
5
1] Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, Canada. [2] Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, H2W 1S6, Canada.

Abstract

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold promise as novel anticancer drugs that can overcome intra-tumour heterogeneity. In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.

PMID:
25743081
DOI:
10.1038/nrd4505
[Indexed for MEDLINE]

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