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Lancet. 1989 Dec 9;2(8676):1363-5.

Prenatal sex determination by DNA amplification from maternal peripheral blood.

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1
University of Oxford Clinical School.

Abstract

The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.

PMID:
2574306
DOI:
10.1016/s0140-6736(89)91969-7
[Indexed for MEDLINE]

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