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Br J Cancer. 2015 Apr 28;112(9):1546-8. doi: 10.1038/bjc.2015.78. Epub 2015 Mar 5.

Age-specific risk of breast cancer in women with neurofibromatosis type 1.

Author information

1
Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.

Abstract

BACKGROUND:

Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might have implications for screening programmes. Our aim was to calculate this risk.

METHODS:

An all-England linked data set of hospital admissions and deaths was analysed to determine age-specific rates of breast cancer in women with NF1 and controls.

RESULTS:

The age-specific excess risk of breast cancer, comparing the NF1 cohort with the control cohort, was elevated 6.5-fold (95% confidence interval 2.6-13.5) in women aged 30-39 years. There was a 4.4 (2.5-7.0) times higher risk among women aged 40-49.

CONCLUSIONS:

Women with NF1 develop breast cancer at younger ages than the general population.

PMID:
25742481
PMCID:
PMC4453683
DOI:
10.1038/bjc.2015.78
[Indexed for MEDLINE]
Free PMC Article

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