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Neuron. 2015 Mar 4;85(5):1013-28. doi: 10.1016/j.neuron.2015.02.003.

Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit.

Author information

1
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: alexward@stanford.edu.
2
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA.
3
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: lluo@stanford.edu.

Abstract

Our understanding of the mechanisms that establish wiring specificity of complex neural circuits is far from complete. During Drosophila olfactory circuit assembly, axons of 50 olfactory receptor neuron (ORN) classes and dendrites of 50 projection neuron (PN) classes precisely target to 50 discrete glomeruli, forming parallel information-processing pathways. Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the targeting of specific classes of PN dendrites and ORN axons, respectively. The canonical ligands and downstream partners of Toll receptors in embryonic patterning and innate immunity are not required for the function of Toll-6/Toll-7 in wiring specificity, nor are their cytoplasmic domains. Interestingly, both Toll-6 and Toll-7 participate in synaptic partner matching between ORN axons and PN dendrites. Our investigations reveal that olfactory circuit assembly involves dynamic and long-range interactions between PN dendrites and ORN axons.

PMID:
25741726
PMCID:
PMC4351475
DOI:
10.1016/j.neuron.2015.02.003
[Indexed for MEDLINE]
Free PMC Article

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