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J Periodontol. 2015 Jul;86(7):847-55. doi: 10.1902/jop.2015.140716. Epub 2015 Mar 5.

The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): A Randomized Controlled Trial.

Author information

1
School of Medicine, The University of Queensland, Brisbane, Australia.
2
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, New Zealand.
3
School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia.
4
Metro North Hospital and Health Service, The Prince Charles Hospital, Queensland, Australia.

Abstract

BACKGROUND:

Triclosan toothpaste is effective in controlling plaque and gingivitis and slowing progression of periodontitis; however, its influence on inflammatory biomarkers of cardiovascular disease (CVD), as well as on kidney and liver function, is unknown.

METHODS:

Patients recruited from the Cardiovascular Unit at Prince Charles Hospital, Brisbane, Australia, were randomized to triclosan (n = 193) or placebo (n = 190) groups and assessed for total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, triglycerides, C-reactive protein, erythrocyte sedimentation rate (ESR), hemoglobin, total white cell count (WCC), estimated glomerular filtration rate (eGFR), and liver function enzymes, annually for 5 years. A standard mixed model for each marker included group, sex, age, hypertension, diabetes, periodontal status, statin and anti-inflammatory drug use, and smoking as covariates. Changes in eGFR, WCC, and ESR were further analyzed using transition modeling.

RESULTS:

Triclosan toothpaste led to a greater decrease in TC (P = 0.03), LDL cholesterol (P = 0.04), and HDL cholesterol (P = 0.05) than placebo toothpaste. ESR increased at a slower rate in the triclosan group (P ≈ 0.06) and was less likely to increase and more likely to improve in males on statins but not anti-inflammatory drugs in the triclosan group versus the placebo group. Markov modeling of the binary response for eGFR (greater than or less than/equal to the baseline median value) showed that patients with diabetes in the placebo group were significantly (P ≈ 0.05) more likely to deteriorate than either patients with diabetes in the triclosan group or patients without diabetes in each group.

CONCLUSIONS:

These data suggest that triclosan toothpaste may influence some inflammatory biomarkers of CVD, but not kidney or liver function. However, it is unclear if this influence is clinically significant.

KEYWORDS:

Biological markers; cardiovascular diseases; glomerular filtration rate; liver function tests; toothpastes; triclosan

PMID:
25741582
DOI:
10.1902/jop.2015.140716
[Indexed for MEDLINE]

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