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Cell Metab. 2015 Mar 3;21(3):355-6. doi: 10.1016/j.cmet.2015.02.013.

A mitochondrially encoded hormone ameliorates obesity and insulin resistance.

Author information

1
Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland.
2
Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland. Electronic address: michael-ristow@ethz.ch.

Abstract

MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.

PMID:
25738453
DOI:
10.1016/j.cmet.2015.02.013
[Indexed for MEDLINE]
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