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Cell Metab. 2015 Mar 3;21(3):349-50. doi: 10.1016/j.cmet.2015.02.011.

Metabolic switches linked to pluripotency and embryonic stem cell differentiation.

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Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:


Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.

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