Format

Send to

Choose Destination
Chem Commun (Camb). 2015 Apr 7;51(27):5971-4. doi: 10.1039/c5cc00780a. Epub 2015 Mar 4.

Synthesis of pyrroloindolines and furoindolines via cascade dearomatization of indole derivatives with carbenium ion.

Author information

1
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China. slyou@sioc.ac.cn.

Abstract

A highly efficient intermolecular cascade dearomatization of substituted indoles with benzodithiolylium tetrafluoroborate has been developed. This reaction provides a novel strategy to synthesise C3 methyl-substituted pyrroloindolines and furoindolines under mild reaction conditions, the utility of which has been demonstrated by the synthesis of esermethol and physovenine in a highly concise manner.

PMID:
25735950
DOI:
10.1039/c5cc00780a
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center