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Eur J Hum Genet. 2015 Nov;23(11):1584-7. doi: 10.1038/ejhg.2015.11. Epub 2015 Mar 4.

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease.

Author information

1
Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
2
Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USA.
3
College of Nursing, The University of Iowa, Iowa City, IA, USA.
4
Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
5
Department of Psychology, The University of Iowa, Iowa City, IA, USA.

Abstract

The Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5), recommends the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 for routine clinical use. We tested the utility of the 12-item WHODAS 2.0 in prodromal Huntington disease. Using data from 726 participants and 630 companions over a 3-year follow-up, linear mixed models were fitted to test (1) baseline and longitudinal differences by progression group; (2) participant and companion differences within each group; and (3) sensitivity of the 12-item WHODAS in comparison to the 36-item WHODAS and the Total Functional Capacity (TFC) score from the Unified Huntington's Disease Rating Scale. Participants showed baseline group differences whereas companions showed baseline and longitudinal group differences. Companions reported worse functional decline over time than participants as the disease progresses. The 12-item WHODAS detected longitudinal change better than the 36-item WHODAS and the TFC in the medium progression group. Results suggest the 12-item WHODAS 2.0 can detect baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials.

PMID:
25735480
PMCID:
PMC4613468
DOI:
10.1038/ejhg.2015.11
[Indexed for MEDLINE]
Free PMC Article

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