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Molecules. 2015 Feb 27;20(3):3841-53. doi: 10.3390/molecules20033841.

Anti-tumor activity of a polysaccharide from blueberry.

Author information

1
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. sun_xiyun@163.com.
2
College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, China. lnbrisk@163.com.
3
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. wuzxsau@163.com.
4
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. fywjg@sina.com.
5
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. mengxjsy@126.com.

Abstract

Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg-1·d-1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.

PMID:
25734419
PMCID:
PMC6272434
DOI:
10.3390/molecules20033841
[Indexed for MEDLINE]
Free PMC Article

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