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Clin Interv Aging. 2015 Feb 16;10:487-90. doi: 10.2147/CIA.S75319. eCollection 2015.

The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat.

Author information

1
Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
2
Department of Clinical Pharmacology, Changhai Hospital Affiliated Second Military Medical University, Shanghai, People's Republic of China.

Abstract

Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.

KEYWORDS:

axonal regeneration; bone marrow mesenchymal stem cell; nervous system disorders; rat optic nerve crush

PMID:
25733825
PMCID:
PMC4337419
DOI:
10.2147/CIA.S75319
[Indexed for MEDLINE]
Free PMC Article

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