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Antimicrob Agents Chemother. 2015 May;59(5):2944-8. doi: 10.1128/AAC.04952-14. Epub 2015 Mar 2.

Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs.

Author information

  • 1Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 2W. M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.
  • 3University of California, Davis, California, USA.
  • 4School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 5W. M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA erosen@ncsu.edu.

Abstract

Persistent HIV replication within active viral reservoirs may be caused by inadequate antiretroviral penetration. Here, we used mass spectrometry imaging with infrared matrix-assisted laser desorption-electrospray ionization to quantify the distribution of efavirenz within tissues from a macaque dosed orally to a steady state. Intratissue efavirenz distribution was heterogeneous, with the drug concentrating in the lamina propria of the colon, the primary follicles of lymph nodes, and the brain gray matter. These are the first imaging data of an antiretroviral drug in active viral reservoirs.

PMID:
25733502
PMCID:
PMC4394831
DOI:
10.1128/AAC.04952-14
[PubMed - indexed for MEDLINE]
Free PMC Article
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