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J Mol Microbiol Biotechnol. 2014;24(5-6):384-95. doi: 10.1159/000368931. Epub 2015 Feb 17.

Structural maintenance of chromosome complex in bacteria.

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Division of Biological Sciences and Section of Molecular Biology, University of California, San Diego, La Jolla, Calif., USA.


In all organisms, from eukaryotes to prokaryotes, the chromosome is highly compacted and organized. Chromosome condensation is essential in all cells and ranges from 1,000- to more than 10,000-fold between bacterial and eukaryotic cells. Replication and transcription occur in parallel with chromosome segregation in bacteria. Structural maintenance of chromosome proteins play a key role in chromosome compaction and segregation, their coordination with the cell cycle, and in various other chromosome dynamics, including DNA repair. In spite of their essential nature in almost all organisms, their function at a molecular level is only slowly beginning to emerge.

[Indexed for MEDLINE]

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