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Biomark Med. 2015;9(3):187-97. doi: 10.2217/bmm.14.115.

Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.

Author information

1
Centre de Recherche sur le Cancer de l'Université Laval, 9 McMahon Street, Québec City, Québec, Canada.

Abstract

AIM:

We determined whether the Y-box binding protein-1 (YB-1) and its binding partner, the X-linked ribosomal protein S4 (RPS4X), are associated with clinical outcome in bladder cancer.

MATERIALS & METHODS:

A population of 167 patients with muscle-invasive bladder tumor without evidence of metastasis at time of cystectomy was analyzed retrospectively. YB-1 and RPS4X expressions were evaluated immunohistochemically in tumors and analyzed for association with clinical variables and survival.

RESULTS:

Kaplan-Meier and multivariate Cox regression analyses indicated that low expression of RPS4X was associated with a higher risk of death or disease recurrence. In contrast, YB-1 was not significantly associated with either recurrence-free or overall survival.

CONCLUSION:

Low RPS4X expression is associated with poor disease-specific and recurrence-free survival in bladder cancer.

KEYWORDS:

RPS4X; YB-1; bladder cancer; disease outcome; immunohistochemistry; prognostic biomarker

PMID:
25731206
DOI:
10.2217/bmm.14.115
[Indexed for MEDLINE]

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