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Nat Neurosci. 2015 Apr;18(4):490-2. doi: 10.1038/nn.3963. Epub 2015 Mar 2.

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.

Author information

1
1] Institute of Stem Cell Research, Helmholtz Center, Munich, Germany. [2] Biomedical Center, University of Munich, Munich, Germany.
2
Institute of Stem Cell Research, Helmholtz Center, Munich, Germany.
3
1] Institute of Computational Biology, Helmholtz Center, Munich, Germany. [2] Institute for Mathematical Sciences, Technical University Munich, Garching, Germany.
4
1] Institute of Stem Cell Research, Helmholtz Center, Munich, Germany. [2] Biomedical Center, University of Munich, Munich, Germany. [3] Munich cluster for Systems Neurology (SYNERGY), Ludwig-Maximilians-Universität, München, Germany.

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

PMID:
25730673
DOI:
10.1038/nn.3963
[Indexed for MEDLINE]

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