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Am J Perinatol. 2015 Aug;32(10):973-9. doi: 10.1055/s-0035-1545666. Epub 2015 Mar 2.

Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection.

Author information

1
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
2
Department of Pediatrics, Wayne State University, Detroit, Michigan.
3
Department of Pediatrics, Women and Infants' Hospital, Brown University, Providence, Rhode Island.
4
Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina.
5
Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.
6
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
7
Department of Pediatrics, University of Iowa, Iowa City, Iowa.
8
Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland.

Abstract

OBJECTIVE:

The aim of this study is to determine whether the cystic periventricular leukomalacia (cPVL) detection rate differs between imaging studies performed at different time points.

DESIGN:

We retrospectively reviewed the prospectively collected data of 31,708 infants from the NICHD Neonatal Research Network. Inclusion criteria were infants < 1,000 g birth weight or < 29 weeks' gestational age who had cranial imaging performed using both early criterion (cranial ultrasound [CUS] < 28 days chronological age) and late criterion (CUS, magnetic resonance imaging, or computed tomography closest to 36 weeks postmenstrual age [PMA]). We compared the frequency of cPVL diagnosed by early and late criteria.

RESULTS:

About 664 (5.2%) of the 12,739 infants who met inclusion criteria had cPVL using either early or late criteria; 569 using the late criterion, 250 using the early criterion, and 155 patients at both times. About 95 (14.3%) of 664 cPVL cases seen on early imaging were no longer visible on repeat screening closest to 36 weeks PMA. Such disappearance of cPVL was more common in infants < 26 weeks' gestation versus infants of 26 to 28 weeks' gestation (18.5 vs. 11.5%; p = 0.013).

CONCLUSIONS:

Cranial imaging at both < 28 days chronological age and closest to 36 weeks PMA improves cPVL detection, especially for more premature infants.

PMID:
25730135
PMCID:
PMC4697863
DOI:
10.1055/s-0035-1545666
[Indexed for MEDLINE]
Free PMC Article

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