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Am J Perinatol. 2015 May;32(6):591-8. doi: 10.1055/s-0035-1544947. Epub 2015 Mar 2.

Relation between birth weight and weight and height at the age of 2 in children born preterm.

Author information

1
Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas.
2
Department of Obstetrics and Gynecology, The George Washington University Biostatistics Center, Washington, District of Columbia.
3
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
4
Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio.
5
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.
6
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
7
Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio.
8
Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania.
9
Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas.
10
Department of Obstetrics and Gynecology, Columbia University, New York, New York.
11
Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island.
12
Department of Obstetrics and Gynecology, University of Miami, Miami, Florida.
13
Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, Illinois.
14
Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Abstract

OBJECTIVE:

The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight.

STUDY DESIGN:

This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile.

RESULTS:

Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R (2) = 0.04 and 0.02, respectively).

CONCLUSION:

Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.

PMID:
25730133
PMCID:
PMC4485423
DOI:
10.1055/s-0035-1544947
[Indexed for MEDLINE]
Free PMC Article

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