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Org Lett. 2015 Mar 20;17(6):1557-60. doi: 10.1021/acs.orglett.5b00442. Epub 2015 Mar 2.

Successively recycle waste as catalyst: a one-pot Wittig/1,4-reduction/Paal-Knorr sequence for modular synthesis of substituted furans.

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†Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China.
‡Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P. R. China.
§State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, P. R. China.


A one-pot tandem Wittig/conjugate reduction/Paal-Knorr reaction is reported for the synthesis of di- or trisubstituted furans. This novel sequence first demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.

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