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Neurosci Lett. 1989 Sep 25;104(1-2):13-8.

Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.

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1
Sandoz Preclinical Research, Basel, Switzerland.

Abstract

In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octapeptide SMS 201-995 solely inhibits the forskolin-activated adenylate cyclase in the 3 preparations. These results suggest that the SRIF-specific stimulation of adenylate cyclase may be a functional correlate for the brain-specific SRIF receptor subpopulation, whereas the SRIF and SMS 201-995 inhibition of stimulated adenylate cyclase correlate with the SRIF receptor subpopulation present in brain and non-neuronal tissues.

PMID:
2573010
[Indexed for MEDLINE]
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