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J Clin Invest. 2015 Mar 2;125(3):939-48. doi: 10.1172/JCI76305. Epub 2015 Mar 2.

Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.

Abstract

Bariatric surgery is the most effective treatment for severe obesity, producing marked sustained weight loss with associated reduced morbidity and mortality. Roux-en-Y gastric bypass surgery (RYGBP), the most commonly performed procedure, was initially viewed as a hybrid restrictive-malabsorptive procedure. However, over the last decade, it has become apparent that alternative physiologic mechanisms underlie its beneficial effects. RYGBP-induced altered feeding behavior, including reduced appetite and changes in taste/food preferences, is now recognized as a key driver of the sustained postoperative weight loss. The brain ultimately determines feeding behavior, and here we review the mechanisms by which RYGBP may affect central appetite-regulating pathways.

PMID:
25729850
PMCID:
PMC4362264
DOI:
10.1172/JCI76305
[Indexed for MEDLINE]
Free PMC Article

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