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Neurologia. 2017 Jul - Aug;32(6):394-398. doi: 10.1016/j.nrl.2014.12.016. Epub 2015 Feb 26.

Caffeine and headache: specific remarks.

[Article in English, Spanish]

Author information

1
Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia. Electronic address: camilo_jovel@hotmail.com.
2
Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia.

Abstract

Caffeine is the most widely used psychostimulant worldwide. Excessive caffeine consumption induces a series of both acute and chronic biological and physiological changes that may give rise to cognitive decline, depression, fatigue, insomnia, cardiovascular changes, and headache. Chronic consumption of caffeine promotes a pro-nociceptive state of cortical hyperexcitability that can intensify a primary headache or trigger a headache due to excessive analgesic use. This review offers an in-depth analysis of the physiological mechanisms of caffeine and its relationship with headache.

KEYWORDS:

Adenosina; Adenosine; Adultos; Adults; Analgesics; Analgésicos; Cafeína; Caffeine; Cefalea crónica diaria; Daily chronic headache; Migraine; Migraña

PMID:
25728949
DOI:
10.1016/j.nrl.2014.12.016
[Indexed for MEDLINE]
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