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Lancet. 1989 Oct 28;2(8670):997-1000.

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man.

Author information

1
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London.

Abstract

NG monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy volunteers to study the role of NO in the control of forearm blood flow. L-NMMA caused a 50% fall in basal blood flow and attenuated the dilator response to infused acetylcholine but not that to glyceryl trinitrate. These results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man. Impairment of production of NO might account for the abnormalities in vascular reactivity that characterise a wide variety of disease states.

PMID:
2572793
DOI:
10.1016/s0140-6736(89)91013-1
[Indexed for MEDLINE]

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