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Int J Hyg Environ Health. 2015 May;218(3):324-30. doi: 10.1016/j.ijheh.2015.01.005. Epub 2015 Jan 31.

Urinary phthalate metabolite concentrations and blood glucose levels during pregnancy.

Author information

1
Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309, Oklahoma City, OK 73104, USA. Electronic address: candace.robledo@unthsc.edu.
2
Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309, Oklahoma City, OK 73104, USA. Electronic address: jennifer-peck@ouhsc.edu.
3
Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309, Oklahoma City, OK 73104, USA. Electronic address: julie-stoner@ouhsc.edu.
4
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention (CDC), 4770 Buford Hwy, Atlanta, GA 30341, USA. Electronic address: acalafat@cdc.gov.
5
Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309, Oklahoma City, OK 73104, USA. Electronic address: helene-carabin@ouhsc.edu.
6
Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309, Oklahoma City, OK 73104, USA. Electronic address: linda-cowan@ouhsc.edu.
7
Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, Stritch School of Medicine, Loyola University Health System, 2160 South First Avenue, Building 103, Maywood, IL 60153, USA. Electronic address: jrgoodman@lumc.edu.

Abstract

PURPOSE:

To examine associations between phthalate metabolite urinary concentrations during early pregnancy and blood glucose levels obtained at the time of screening for gestational diabetes mellitus (GDM).

METHODS:

Upon initiation of prenatal care, women with a mean gestational age of 12.8 weeks were recruited for a study of environmental chemical exposures (n = 110) and provided a spot urinary specimen. Blood glucose concentrations (mg/dl) were obtained from the electronic medical record for those patients who did not experience a pregnancy loss and did not transfer care to another facility prior to glucose screening (n = 72). Urinary concentrations of nine phthalate metabolites and creatinine were measured at the US Centers for Disease Control and Prevention. Associations between tertiles of phthalate metabolites concentrations and blood glucose levels were estimated using linear regression.

RESULTS:

Compared to pregnant women in the lowest concentration tertile, women with the highest urinary concentrations (≥ 3 rd tertile) of mono-iso-butyl phthalate (tertile: ≥ 15.3 μg/l, β = -18.3, 95% CI: -35.4, -1.2) and monobenzyl phthalate (tertile: ≥ 30.3 μg/l, β = -17.3, 95% CI: -34.1, -0.4) had lower blood glucose levels at the time of GDM screening after adjustment for urinary creatinine and demographic covariates.

CONCLUSION:

Because maternal glucose levels increase during pregnancy to provide adequate nutrition for fetal growth and development, these findings may have implications for fetal health. However, given the limitations of our study, findings should be interpreted cautiously.

KEYWORDS:

Blood glucose; Mono-2-ethyl-5-carboxypentyl phthalate (PubChem CID: 148386); Mono-2-ethyl-5-hydroxyhexyl phthalate (PubChem CID: 53437104); Mono-2-ethyl-5-oxohexyl phthalate (PubChem CID: 12080048); Mono-2-ethylhexyl phthalate (PubChem CID: 20393); Mono-3-carboxypropyl phthalate (PubChem CID: 53435015); Mono-iso-butyl phthalate (PubChem CID: 92272); Mono-n-butyl phthalate (PubChem CID: 8575); Monobenzyl phthalate (PubChem CID: 31736); Monoethyl phthalate (PubChem CID: 75318); Phthalate; Pregnancy

PMID:
25726127
PMCID:
PMC4724204
DOI:
10.1016/j.ijheh.2015.01.005
[Indexed for MEDLINE]
Free PMC Article

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