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Exp Eye Res. 2015 May;134:101-10. doi: 10.1016/j.exer.2015.02.019. Epub 2015 Feb 25.

Vitamin D: Implications for ocular disease and therapeutic potential.

Author information

1
The Ocular Surface Institute, University of Houston College of Optometry, 4901 Calhoun Road, Houston, TX 77204-2020, USA. Electronic address: rose@reins.org.
2
The Ocular Surface Institute, University of Houston College of Optometry, 4901 Calhoun Road, Houston, TX 77204-2020, USA. Electronic address: AMcdermott@OPTOMETRY.UH.EDU.

Abstract

Vitamin D is a multifunctional hormone that is now known to play a significant role in a variety of biological functions in addition to its traditional role in regulating calcium homeostasis. There are a large number of studies demonstrating that adequate vitamin D levels are important in maintaining health and show that vitamin D is able to be utilized at local tissue sites. In the eye, we have increasing evidence of the association between disease and vitamin D. In this narrative review, we summarize recent findings on vitamin D and its relationship to various ocular pathologies and the therapeutic potential for some of these, as well as examine the basic science studies that demonstrate that vitamin D is biologically relevant in the eye.

KEYWORDS:

Anti-inflammatory; Deficiency; Genetic variations; Ocular disease; Vitamin D

PMID:
25724179
PMCID:
PMC4426046
DOI:
10.1016/j.exer.2015.02.019
[Indexed for MEDLINE]
Free PMC Article

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