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Horm Metab Res. 2015 Apr;47(4):239-46. doi: 10.1055/s-0034-1396893. Epub 2015 Feb 27.

Focus on vitamin D and the adrenal gland.

Author information

1
Department of Clinical Medicine and Surgery, Section of Endocrinology, University "Federico II", Naples, Italy.
2
Institute of Medical Pathology, Division of Endocrinology and Metabolic Disease, Catholic University, Rome, Italy.
3
Division of Endocrinology & Diabetes, Department of Medicine 1, Center of Internal Medicine, University Hospital, Goethe-University, Frankfurt am Main, Germany.

Abstract

The main role of vitamin D is to maintain calcium and phosphorus homeostasis, thus preserving bone health. However, recent evidences have demonstrated that vitamin D may also play a role in a variety of nonskeletal disorders such as endocrine diseases and in particular type 1 diabetes, type 2 diabetes, adrenal diseases, and the polycystic ovary syndrome. Despite controversial results on an association of low vitamin D levels with cortisol and aldosterone overproduction, encouraging in vitro findings have been reported on vitamin D effects in adrenocortical cancer cells. The focus of this review is the role of vitamin D in adrenal diseases and the results of vitamin D supplementation studies in patients. Although many studies support a beneficial role of vitamin D in adrenal disease, randomized controlled trials and mechanistic studies are required to provide more insight into the efficacy and safety of vitamin D as a therapeutic tool.

PMID:
25723858
DOI:
10.1055/s-0034-1396893
[Indexed for MEDLINE]

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