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Horm Metab Res. 2015 Apr;47(4):239-46. doi: 10.1055/s-0034-1396893. Epub 2015 Feb 27.

Focus on vitamin D and the adrenal gland.

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Department of Clinical Medicine and Surgery, Section of Endocrinology, University "Federico II", Naples, Italy.
Institute of Medical Pathology, Division of Endocrinology and Metabolic Disease, Catholic University, Rome, Italy.
Division of Endocrinology & Diabetes, Department of Medicine 1, Center of Internal Medicine, University Hospital, Goethe-University, Frankfurt am Main, Germany.


The main role of vitamin D is to maintain calcium and phosphorus homeostasis, thus preserving bone health. However, recent evidences have demonstrated that vitamin D may also play a role in a variety of nonskeletal disorders such as endocrine diseases and in particular type 1 diabetes, type 2 diabetes, adrenal diseases, and the polycystic ovary syndrome. Despite controversial results on an association of low vitamin D levels with cortisol and aldosterone overproduction, encouraging in vitro findings have been reported on vitamin D effects in adrenocortical cancer cells. The focus of this review is the role of vitamin D in adrenal diseases and the results of vitamin D supplementation studies in patients. Although many studies support a beneficial role of vitamin D in adrenal disease, randomized controlled trials and mechanistic studies are required to provide more insight into the efficacy and safety of vitamin D as a therapeutic tool.

[Indexed for MEDLINE]

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