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Brain Res Dev Brain Res. 1989 Oct 1;49(2):305-10.

Direct visualisation of the soluble pool of tubulin in the neuronal growth cone: immunofluorescence studies following taxol polymerisation.

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Department of Anatomy and Human Biology, King's College, London, U.K.


Previously we have shown that the predominant form of soluble alpha-tubulin in the growth cone is C-terminally tyrosinated (Gordon-Weeks and Lang. Dev. Brain Res., 42 (1988) 156-160). Here we show that when growth cones are incubated in taxol, this soluble pool of alpha-tubulin is polymerised onto the ends of the neurite microtubules that enter the proximal part of the growth cone indicating that it is assembly-competent.

[Indexed for MEDLINE]

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