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Cell. 2015 Feb 26;160(5):809-811. doi: 10.1016/j.cell.2015.02.007.

Finding the right match fast.

Author information

1
Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
2
Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA. Electronic address: patelss@rutgers.edu.

Abstract

DNA recombinases face the daunting task of locating and pairing up specific sequences among millions of base pairs in a genome, all within about an hour. Qi et al. show that recombinases solve this problem by searching in 8-nt microhomology units, reducing the search space and accelerating the homology search.

PMID:
25723158
DOI:
10.1016/j.cell.2015.02.007
[Indexed for MEDLINE]
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