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Cell. 2015 Feb 26;160(5):807-809. doi: 10.1016/j.cell.2015.02.027.

For longevity, perception is everything.

Author information

1
Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA.
2
Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA. Electronic address: ctmurphy@princeton.edu.

Abstract

Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.

PMID:
25723157
DOI:
10.1016/j.cell.2015.02.027
[Indexed for MEDLINE]
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