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Pathog Dis. 2015 Mar;73(2):1-3. doi: 10.1093/femspd/ftu010. Epub 2014 Dec 4.

Imbalance of circulating lymphoid cells in Q fever endocarditis.

Author information

1
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France mignouk@yahoo.fr.
2
Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
3
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France.

Abstract

Q fever endocarditis is characterized by a defective cell-mediated immune response, which may be associated with the dysregulation of circulating subsets of immune cells. In this study, we found that naïve CD8(+) T lymphocytes and CD56dim natural killer cells were decreased patients whereas central memory CD8(+) T lymphocytes were increased. It is likely that these different subsets of immune cells play a role in the immunosuppression accompanying Q fever endocarditis.

KEYWORDS:

Q fever; endocarditis; flow cytometry; lymphoid compartment

PMID:
25722485
DOI:
10.1093/femspd/ftu010
[Indexed for MEDLINE]

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