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Cold Spring Harb Perspect Med. 2015 Feb 26;5(5):a023044. doi: 10.1101/cshperspect.a023044.

The human placental methylome.

Author information

1
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada Child & Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.

Abstract

This review provides an overview of the unique features of DNA methylation in the human placenta. We discuss the importance of understanding placental development, structure, and function in the interpretation of DNA methylation data. Examples are given of how DNA methylation is important in regulating placental-specific gene expression, including monoallelic expression and X-chromosome inactivation in the placenta. We also discuss studies of global DNA methylation changes in the context of placental pathology and environmental exposures.

PMID:
25722473
PMCID:
PMC4448590
DOI:
10.1101/cshperspect.a023044
[Indexed for MEDLINE]
Free PMC Article

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