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Cold Spring Harb Perspect Biol. 2015 Feb 26;7(6). pii: a015792. doi: 10.1101/cshperspect.a015792.

Chromosome Dynamics during Mitosis.

Author information

1
Chromosome Dynamics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan.

Abstract

The primary goal of mitosis is to partition duplicated chromosomes into daughter cells. Eukaryotic chromosomes are equipped with two distinct classes of intrinsic machineries, cohesin and condensins, that ensure their faithful segregation during mitosis. Cohesin holds sister chromatids together immediately after their synthesis during S phase until the establishment of bipolar attachments to the mitotic spindle in metaphase. Condensins, on the other hand, attempt to "resolve" sister chromatids by counteracting cohesin. The products of the balancing acts of cohesin and condensins are metaphase chromosomes, in which two rod-shaped chromatids are connected primarily at the centromere. In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin. Recent studies uncover how this series of events might be mechanistically coupled with each other and intricately regulated by a number of regulatory factors.

PMID:
25722466
PMCID:
PMC4448609
DOI:
10.1101/cshperspect.a015792
[Indexed for MEDLINE]
Free PMC Article

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