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Semin Cell Dev Biol. 2015 Apr;40:60-71. doi: 10.1016/j.semcdb.2015.02.008. Epub 2015 Feb 23.

Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.

Author information

1
La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia.
2
Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
3
La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address: Richard.simpson@latrobe.edu.au.

Abstract

Epithelial-mesenchymal transition (EMT) is a highly conserved process defined by the loss of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its central role in development, EMT has been implicated as a cellular process during tumourigenesis which facilitates tumour cell invasion and metastasis. The EMT process has been largely defined by signal transduction networks and transcriptional factors that activate mesenchymal-associated gene expression. Knowledge of secretome components that influence EMT including secreted proteins/peptides and membrane-derived extracellular vesicles (EVs) (i.e., exosomes) has emerged. Here we review EV cargo associated with inducing the hallmarks of EMT and cancer progression, modulators of cell transformation, invasion/migration, angiogenesis, and components involved in establishing the metastatic niche.

KEYWORDS:

Cancer progression; EMT; Epithelial–mesenchymal transition; Exosomes; Extracellular vesicles; Microparticles

PMID:
25721809
DOI:
10.1016/j.semcdb.2015.02.008
[Indexed for MEDLINE]

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