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Methods Mol Biol. 2015;1282:1-23. doi: 10.1007/978-1-4939-2438-7_1.

Coronaviruses: an overview of their replication and pathogenesis.

Author information

1
Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.

Abstract

Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).

PMID:
25720466
PMCID:
PMC4369385
DOI:
10.1007/978-1-4939-2438-7_1
[Indexed for MEDLINE]
Free PMC Article

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