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Brain Imaging Behav. 2016 Mar;10(1):12-20. doi: 10.1007/s11682-015-9358-8.

Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder.

Cai C1,2, Yuan K3,4, Yin J1,2, Feng D1,2, Bi Y1,2, Li Y1,2, Yu D5, Jin C6, Qin W1,2, Tian J1,2,7.

Author information

1
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China.
2
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
3
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China. kyuan@xidian.edu.cn.
4
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. kyuan@xidian.edu.cn.
5
Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. fmydh1@gmail.com.
6
Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
7
Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Abstract

Internet gaming disorder (IGD), identified in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Section III as a condition warranting more clinical research, may be associated with impaired cognitive control. Previous IGD-related studies had revealed structural abnormalities in the prefrontal cortex, an important part of prefrontal-striatal circuits, which play critical roles in cognitive control. However, little is known about the relationship between the striatal nuclei (caudate, putamen, and nucleus accumbens) volumes and cognitive control deficit in individuals with IGD. Twenty-seven adolescents with IGD and 30 age-, gender- and education-matched healthy controls participated in this study. The volume differences of the striatum were assessed by measuring subcortical volume in FreeSurfer. Meanwhile, the Stroop task was used to detect cognitive control deficits. Correlation analysis was used to investigate the relationship between striatal volumes and performance in the Stroop task as well as severity in IGD. Relative to controls, the IGD committed more incongruent condition response errors during the Stroop task and showed increased volumes of dorsal striatum (caudate) and ventral striatum (nucleus accumbens). In addition, caudate volume was correlated with Stroop task performance and nucleus accumbens (NAc) volume was associated with the internet addiction test (IAT) score in the IGD group. The increased volumes of the right caudate and NAc and their association with behavioral characteristics (i.e., cognitive control and severity) in IGD were detected in the present study. Our findings suggest that the striatum may be implicated in the underlying pathophysiology of IGD.

KEYWORDS:

Cognitive control; Color-word Stroop task; Internet gaming disorder (IGD); Striatum; Structural magnetic resonance imaging

PMID:
25720356
DOI:
10.1007/s11682-015-9358-8
[Indexed for MEDLINE]

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