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Neurodegener Dis. 2015;15(2):109-13. doi: 10.1159/000369812. Epub 2015 Feb 20.

Antecedent Disease is Less Prevalent in Amyotrophic Lateral Sclerosis.

Author information

1
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Ga., USA.

Abstract

BACKGROUND/AIMS:

Recent studies suggest that antecedent disease could impact the pathophysiology of the motoneuron disease Amyotrophic Lateral Sclerosis (ALS). We performed a case-control study to examine the prevalence of 11 antecedent diseases in ALS.

METHODS:

Prevalence of antecedent disease in a 1,288 patient ALS population (Emory University ALS Clinic, Atlanta, Ga., USA) is compared to an age, gender, and geography-matched 7,561 subject control population using a statistical odds ratio (OR) with 95% confidence interval.

RESULTS:

Association of ALS with odds of arthritis (OR = 0.14); non-ALS neurological disease (OR = 0.14); liver disease (OR = 0.19); chronic obstructive pulmonary disorder or COPD (OR = 0.23); kidney disease (OR = 0.32); adult asthma (OR = 0.39); diabetes (OR = 0.47); hypertension (OR = 0.56); obesity (OR = 0.6); hyperlipidemia or hypercholesterolemia (OR = 0.62); and thyroid disease (OR = 0.78).

CONCLUSIONS:

The prevalence of antecedent disease was overall less in the ALS population. We present two potential lines of inquiry to explain these results: (1) 'Other disease as ALS protection'--antecedent diseases infer biochemical neuroprotection to ALS; (2) 'ALS as other disease protection'--the underpinnings of ALS could infer protection to other diseases, possibly via the mechanism hypervigilant regulation or 'too-high' regulatory feedback gains.

PMID:
25720304
PMCID:
PMC4417009
DOI:
10.1159/000369812
[Indexed for MEDLINE]
Free PMC Article

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