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Nature. 1989 Oct 19;341(6243):624-30.

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.

Author information

1
Cold Spring Harbor Laboratory, New York 11724.

Abstract

The herpes simplex virus transactivator VP16 participates in the formation of a multiprotein-DNA complex with the ubiquitous octamer-motif-binding factor Oct-1. Complex formation is dependent on specific amino acids in the Oct-1 homoeodomain which are in positions analogous to positive control mutations in helix 2 of the lambda phage repressor helix-turn-helix motif, indicating that this structure is an ancient target for protein-protein interactions mediating transcriptional control.

PMID:
2571937
DOI:
10.1038/341624a0
[Indexed for MEDLINE]

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