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Nature. 1989 Oct 5;341(6241):405-9.

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.

Author information

1
Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK.

Abstract

The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.

PMID:
2571936
DOI:
10.1038/341405a0
[Indexed for MEDLINE]

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