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J Leukoc Biol. 2015 Oct;98(4):523-37. doi: 10.1189/jlb.4MR1114-524R. Epub 2015 Feb 25.

Neutrophils in host defense: new insights from zebrafish.

Author information

1
*Microbiology Doctoral Training Program, Departments of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
2
*Microbiology Doctoral Training Program, Departments of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA huttenlocher@wisc.edu.

Abstract

Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.

KEYWORDS:

infection; innate immunity

PMID:
25717145
PMCID:
PMC4569048
DOI:
10.1189/jlb.4MR1114-524R
[Indexed for MEDLINE]
Free PMC Article

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