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Mult Scler. 2015 May;21(6):791-4. doi: 10.1177/1352458515572241. Epub 2015 Feb 25.

Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4.

Author information

1
Institute of Neurology, Catholic University, Rome, Italy iorio.raffaele@gmail.com.
2
Institute of Anatomic Pathology, Catholic University, Rome, Italy.
3
Institute of Neurology, Catholic University, Rome, Italy.

Abstract

BACKGROUND:

The observations of neuromyelitis optica spectrum disorders (NMOSD) occurring in the setting of cancer suggest that aquaporin-4 (AQP4) autoimmunity may in some cases be paraneoplastic.

RESULTS:

We describe a 72-year-old patient who developed a longitudinally extensive transverse myelitis associated with AQP4 autoantibodies in the setting of a lung adenocarcinoma recurrence. AQP4 expression was demonstrated in tumor cells. IgG in patient's cerebrospinal fluid bound to tumor cells co-localizing with AQP4 immunoreactivity.

CONCLUSIONS AND RELEVANCE:

This case expands the spectrum of paraneoplastic AQP4 autoimmunity highlighting the importance of considering an oncological screening in patients with late-onset NMOSD.

KEYWORDS:

Paraneoplastic; neuromyelitis optica

PMID:
25716881
DOI:
10.1177/1352458515572241
[Indexed for MEDLINE]

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