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J Neuropsychiatry Clin Neurosci. 2015 Winter;27(1):59-64. doi: 10.1176/appi.neuropsych.13070169.

Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies.

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From the Cardiff University, School of Biosciences, Cardiff, United Kingdom (JC). Institute of Human Development, Faculty of Medicine and Human Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester, United Kingdom (CS, NA, DC); Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (CS, DC); Dept. of Neuropsychology, Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom (NA); Centre de Référence National pour la Maladie de Huntington, AP-HP, Groupe Henri Mondor-Albert Chenevier, Créteil, France (M-FB, A-CB-L, CB); University of British Columbia, The Centre for Huntington's disease, Vancouver, Canada (AC, RDS); Leiden University Medical Centre, Department of Neurology, Leiden, The Netherlands (EMD, EPH, RACR); UPMC UnivParis06, UMR_S975 and Inserm, UMR_S975, CRICM and CNRS UMR7225, F-75013, Paris, France (DJ, AD); University College London, Institute of Neurology, London, United Kingdom (GO, JR, MJS, SJT); Brain and Spine Institute (ICM), F-75013, Paris, France (AD); AP-HP Pitie-Salpetriere Hospital, Dept. of Genetics and Cytogenetics, F-75013, Paris, France (AD); University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, Canada (BRL); Service de Psychiatrie, 93G18, EPSVE, 93330 Neuilly-sur-Marne, France (CB); and Dept. of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands (EvD).


The authors report the inter-rater reliability and factor structure of the Short Problem Behaviors Assessment (PBA-s), a semistructured interview to measure severity and frequency of behavioral problems in Huntington's disease. Video recordings of 410 PBA-s interviews were rescored by an independent rater, and Cohen's kappa calculated to assess inter-rater reliability. The mean kappa was 0.74 for severity and 0.76 for frequency scores, whereas weighted kappa (allowing scores to differ by 1 point) was 0.94 for severity and 0.92 for frequency scores. The results of factor analysis were consistent with previous studies using other measures. The authors conclude that the PBA-s is a reliable measure.

[Indexed for MEDLINE]

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