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BJU Int. 2015 Nov;116(5):721-6. doi: 10.1111/bju.13102. Epub 2015 May 11.

Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guérin.

Author information

1
Department of Urology, Ankara University School of Medicine, Ankara, Turkey.
2
Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.
3
Department of Urology, İstanbul Medeniyet University School of Medicine, İstanbul, Turkey.
4
Department of Urology, Marmara University School of Medicine, İstanbul, Turkey.
5
Department of Urology, Dokuz Eylül University School of Medicine Inciralti, Izmir, Turkey.
6
Department of Urology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
7
Department of Urology, Trakya University School of Medicine, Edirne, Turkey.
8
Department of Urology, Bülent Ecevit University School of Medicine, Zonguldak, Turkey.

Abstract

OBJECTIVES:

To evaluate the effect of the interval between the initial and second transurethral resection (TUR) on the outcome of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated with maintenance intravesical Bacillus Calmette-Guérin (BCG) therapy.

PATIENTS AND METHODS:

We reviewed the data of patients from 10 centres treated for high-risk NMIBC between 2005 and 2012. Patients without a diagnosis of muscle-invasive cancer on second TUR performed ≤90 days after a complete first TUR, and received at least 1 year of maintenance BCG were included in this study. The interval between first and second TUR in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression.

RESULTS:

In all, 242 patients were included. The mean (sd, range) follow-up was 29.4 (22.2, 12-96) months. The 3-year recurrence- and progression-free survival rates of patients who underwent second TUR between 14 and 42 days and 43-90 days were 73.6% vs 46.2% (P < 0.001) and 89.1% vs 79.1% (P = 0.006), respectively. On multivariate analysis, the interval to second TUR was found to be a predictor of both recurrence [odds ratio (OR) 3.598, 95% confidence interval (CI) 1.885-8.137; P = 0.001] and progression (OR 2.144, 95% CI 1.447-5.137; P = 0.003).

CONCLUSIONS:

The interval between first and second TUR should be ≤42 days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second TUR on patient outcomes.

KEYWORDS:

Bacillus Calmette-Guérin; maintenance Bacillus Calmette-Guérin; non-muscle-invasive bladder cancer; second transurethral resection

PMID:
25715815
DOI:
10.1111/bju.13102
[Indexed for MEDLINE]
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