Format

Send to

Choose Destination
Cancer Res Treat. 2016 Jan;48(1):415-21. doi: 10.4143/crt.2014.160. Epub 2015 Feb 26.

A Unique Case of Erdheim-Chester Disease with Axial Skeleton, Lymph Node, and Bone Marrow Involvement.

Author information

1
Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
2
Division of Hematology and Medical Oncology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.
3
Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
4
Department of Pathology, SMG-SNU Boramae Medical Center, Seoul, Korea.
5
Department of Laboratory Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.

Abstract

Erdheim-Chester disease is a rare non-Langerhans-cell histiocytosis with bone and organ involvement. A 76-year-old man presented with low back pain and a history of visits for exertional dyspnea. We diagnosed him with anemia of chronic disease, cytopenia related to chronic illness, chronic renal failure due to hypertension, and hypothyroidism. However, we could not determine a definite cause or explanation for the cytopenia. Multiple osteosclerotic axial skeleton lesions and axillary lymph node enlargement were detected by computed tomography. Bone marrow biopsy revealed histiocytic infiltration, which was CD68-positive and CD1a-negative. This report describes an unusual presentation of Erdheim-Chester disease involving the bone marrow, axial skeleton, and lymph nodes.

KEYWORDS:

Axial skeleton; Cytopenia; Lymph nodes; Non-Langerhans-cell histiocytosis

PMID:
25715762
PMCID:
PMC4720080
DOI:
10.4143/crt.2014.160
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center