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Hum Genet. 1989 Oct;83(3):297-9.

Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10.

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  • 1Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.


The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10.

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