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J Leukoc Biol. 2015 May;97(5):837-847. doi: 10.1189/jlb.2RI0814-408R. Epub 2015 Feb 24.

mTOR and metabolic regulation of conventional and regulatory T cells.

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
2
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA hongbo.chi@stjude.org.

Abstract

mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs In this review, we discuss the regulation of mTOR signaling in T cells and the functional impacts of mTOR and metabolic pathways on T cell-mediated immune responses, with a particular focus on the differentiation and function of Tregs.

KEYWORDS:

T cell differentiation; Tregs; glycolysis; lipid; metabolism

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