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N Engl J Med. 2015 Feb 26;372(9):796-7. doi: 10.1056/NEJMp1414786.

Anesthetic neurotoxicity--clinical implications of animal models.

Author information

1
From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (B.A.R., S.H.); Northwestern University Feinberg School of Medicine, Chicago (S.S.); Washington University School of Medicine, St. Louis (A.S.E.); and the Department of Anesthesia and Physiology, University of Toronto, Toronto (B.A.O.).

Abstract

Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.

PMID:
25714157
DOI:
10.1056/NEJMp1414786
[Indexed for MEDLINE]

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