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Bioinformatics. 2015 Jul 1;31(13):2217-9. doi: 10.1093/bioinformatics/btv110. Epub 2015 Feb 23.

GlycanAnalysis Plug-in: a database search tool for N-glycan structures using mass spectrometry.

Author information

1
Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation, Kyoto, Japan and Eisai Product Creation Systems, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan.

Abstract

Tandem mass spectrometry (MS/MS or MS(n)) is a potent technique for characterizing N-glycan structures. GlycanAnalysis searches a glycan database to support the identification of glycan structures from MS/MS spectra. It also calculates diagnostic ions of glycan structures registered in a glycan database (GlycomeDB or KEGG GLYCAN) and searches for MS/MS spectra of N-glycans that match diagnostic ions to determine the structures. This program functions as a plug-in for Mass++, a freeware mass spectrum visualization and analysis program.

AVAILABILITY AND IMPLEMENTATION:

The executable files of Mass++ are available for free at http://www.first-ms3d.jp/english/. The GlycanAnalysis plug-in is included in the standard package of Mass++ for Windows.

CONTACT:

k-morimt@shimadzu.co.jp or nishikaz@shimadzu.co.jp or acyshzw@shimadzu.co.jp

SUPPLEMENTARY INFORMATION:

Supplementary material are available at Bioinformatics online.

PMID:
25712693
DOI:
10.1093/bioinformatics/btv110
[Indexed for MEDLINE]

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