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J Cell Commun Signal. 2015 Mar;9(1):89. doi: 10.1007/s12079-015-0277-7. Epub 2015 Feb 26.

Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion.

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1
Pontificia Universidad Católica de Chile, Santiago, Chile, ebrandan@bio.puc.cl.

Abstract

Fast varying 3-O-sulfated groups in epithelial KIT+ progenitors provides a cellular mechanism to respond to FGFR2b-mediated signaling and expansion of fetal and adult progenitors. This is allowed by the synthesis of 3-O-sulfated heparan sulfate that up-regulate KIT and 3-O-sulfotransferase enzymes, augmenting 3-O-sulfated heparan sulfate.

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