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J Cell Commun Signal. 2015 Mar;9(1):87. doi: 10.1007/s12079-015-0276-8. Epub 2015 Feb 26.

How IGF-1 activates its receptor.

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Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia,


This study presents a new model for IGF-I receptor activation in which the transmembrane domains are held apart until ligand binding brings them together in an activated state.

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