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Nat Genet. 2015 Mar;47(3):196-7. doi: 10.1038/ng.3231.

Big Bang and context-driven collapse.

Author information

1
Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Abstract

Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.

PMID:
25711865
DOI:
10.1038/ng.3231
[Indexed for MEDLINE]

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